Clinical and Morphologic Characteristics of Extracellular Signal-Regulated Kinase Inhibitor-Associated Retinopathy.

ABSTRACT:

Purpose

To investigate clinical and morphologic characteristics of serous retinal disturbances in patients taking extracellular signal-regulated kinase (ERK) inhibitors.

Design

Single-center retrospective study of prospectively collected data.

Participants

Of 61 patients receiving ERK inhibitors for treatment of metastatic cancer, this study included 40 eyes of 20 patients with evidence of retinopathy confirmed by OCT.

Methods

Clinical examination, fundus photography, and OCT were used to evaluate ERK inhibitor retinopathy. The morphologic features, distribution, and location of fluid foci were evaluated serially. Visual acuity (VA) and choroidal thickness measurements were compared at baseline, fluid accumulation, and resolution.

Main outcome measures

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SUBMITTER: Francis JH 

PROVIDER: S-EPMC10977084 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature