Identification of a novel Rev-interacting cellular protein.

ABSTRACT:

Background

Human cell types respond differently to infection by human immunodeficiency virus (HIV). Defining specific interactions between host cells and viral proteins is essential in understanding how viruses exploit cellular functions and the innate strategies underlying cellular control of HIV replication. The HIV Rev protein is a post-transcriptional inducer of HIV gene expression and an important target for interaction with cellular proteins. Identification of Rev-modulating cellular factors may eventually contribute to the design of novel antiviral therapies.

Results

Yeast-two hybrid screening of a T-cell cDNA library with Rev as bait led to isolation of a novel human cDNA product (16.4.1). 16.4.1-containing fusion proteins showed predominant cytoplasmic localization,

SUBMITTER: Kramer-Hammerle S 

PROVIDER: S-EPMC1097722 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature