Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia.
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ABSTRACT:
SUBMITTER: Cirillo R
PROVIDER: S-EPMC10977406 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Publications
Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia.
Cirillo Rossella R Duperrier Sandra S Parekh Pathik P Millot Mathilde M Li Qin Q Thiolat Marie-Laure ML Morelli Micaela M Xie Jing J Le Bars Didier D Redouté Jérôme J Bezard Erwan E Sgambato Véronique V
Journal of Parkinson's disease 20240101 2
Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson's disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striat ...[more]
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