Causal associations between human gut microbiota and hemorrhoidal disease: A two-sample Mendelian randomization study.

ABSTRACT: Hemorrhoidal disease (HEM) is a common condition affecting a significant proportion of the population. However, the causal relationship between the gut microbiota and hemorrhoids remains unclear. In this study, we employed a Mendelian randomization (MR) approach to investigate the potential associations between them. In this study, the exposure factor was determined by selecting summary statistics data from a large-scale gut microbiome whole-genome association study conducted by the MiBioGen Consortium, which involved a sample size of 18,340 individuals. The disease outcome data consisted of 218,920 cases of HEM and 725,213 controls of European ancestry obtained from the European Bioinformatics Institute dataset. Two-sample MR analyses were performed to assess the causalities between gut m

SUBMITTER: Yang F 

PROVIDER: S-EPMC10977532 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature