Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation.

ABSTRACT: The popularity of the ancient, probiotic-rich beverage Kombucha Tea (KT) has surged in part due to its purported health benefits, which include protection against metabolic diseases; however, these claims have not been rigorously tested and the mechanisms underlying host response to the probiotics in KT are unknown. Here, we establish a reproducible method to maintain C. elegans on a diet exclusively consisting of Kombucha Tea-associated microbes (KTM), which mirrors the microbial community found in the fermenting culture. KT microbes robustly colonize the gut of KTM-fed animals and confer normal development and fecundity. Intriguingly, animals consuming KTMs display a marked reduction in total lipid stores and lipid droplet size. We find that the reduced fat accumulation phenotype is not

SUBMITTER: DuMez-Kornegay RN 

PROVIDER: S-EPMC10977768 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature