Stochastic modeling of a gene regulatory network driving B cell development in germinal centers.

ABSTRACT: Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexpected malfunctioning may lead to a range of pathologies, including various malignant formations. One promising way to improve the understanding of malignant transformation is to study the underlying gene regulatory networks (GRNs) associated with cell development and differentiation. Evaluation and inference of the GRN structure from gene expression data is a challenging task in systems biology: recent achievements in single-cell (SC) transcriptomics allow the generation of SC gene expression data, which can be used to sharpen the knowledge on GRN structu

SUBMITTER: Koshkin A 

PROVIDER: S-EPMC10977792 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature