Dataset Information

Melioidosis in Patients with COVID-19 Exposed to Contaminated Tap Water, Thailand, 2021.

ABSTRACT: In September 2021, a total of 25 patients diagnosed with COVID-19 developed acute melioidosis after (median 7 days) admission to a COVID-19 field hospital in Thailand. Eight nonpotable tap water samples and 6 soil samples were culture-positive for Burkholderia pseudomallei. Genomic analysis suggested contaminated tap water as the likely cause of illness.

SUBMITTER: Tantirat P

PROVIDER: S-EPMC10977828 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Melioidosis in Patients with COVID-19 Exposed to Contaminated Tap Water, Thailand, 2021.

Tantirat Panupong P Chantarawichian Yotsathon Y Taweewigyakarn Pantila P Kripattanapong Somkid S Jitpeera Charuttaporn C Doungngern Pawinee P Phiancharoen Chadaporn C Tangwangvivat Ratanaporn R Hinjoy Soawapak S Sujariyakul Anupong A Amornchai Premjit P Wongsuvan Gumphol G Hantakun Viriya V Wuthiekanun Vanaporn V Thaipadungpanit Janjira J Thomson Nicholas R NR Dance David A B DAB Chewapreecha Claire C Batty Elizabeth M EM Limmathurotsakul Direk D

Emerging infectious diseases 20240401 4

In September 2021, a total of 25 patients diagnosed with COVID-19 developed acute melioidosis after (median 7 days) admission to a COVID-19 field hospital in Thailand. Eight nonpotable tap water samples and 6 soil samples were culture-positive for Burkholderia pseudomallei. Genomic analysis suggested contaminated tap water as the likely cause of illness. ...[more]

PMID: 38526300

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Project description:A recent modelling study estimated that there are 2800 deaths due to melioidosis in Thailand yearly. The Thailand Melioidosis Network (formed in 2012) has been working closely with the Ministry of Public Health (MoPH) to investigate and reduce the burden of this disease. Based on updated data, the incidence of melioidosis is still high in Northeast Thailand. More than 2000 culture-confirmed cases of melioidosis are diagnosed in general hospitals with microbiology laboratories in this region each year. The mortality rate is around 35%. Melioidosis is endemic throughout Thailand, but it is still not uncommon that microbiological facilities misidentify Burkholderia pseudomallei as a contaminant or another organism. Disease awareness is low, and people in rural areas neither wear boots nor boil water before drinking to protect themselves from acquiring B. pseudomallei. Previously, about 10 melioidosis deaths were formally reported to the National Notifiable Disease Surveillance System (Report 506) each year, thus limiting priority setting by the MoPH. In 2015, the formally reported number of melioidosis deaths rose to 112, solely because Sunpasithiprasong Hospital, Ubon Ratchathani province, reported its own data (n = 107). Melioidosis is truly an important cause of death in Thailand, and currently reported cases (Report 506) and cases diagnosed at research centers reflect the tip of the iceberg. Laboratory training and communication between clinicians and laboratory personnel are required to improve diagnosis and treatment of melioidosis countrywide. Implementation of rapid diagnostic tests, such as a lateral flow antigen detection assay, with high accuracy even in melioidosis-endemic countries such as Thailand, is critically needed. Reporting of all culture-confirmed melioidosis cases from every hospital with a microbiology laboratory, together with final outcome data, is mandated under the Communicable Diseases Act B.E.2558. By enforcing this legislation, the MoPH could raise the priority of this disease, and should consider implementing a campaign to raise awareness and melioidosis prevention countrywide.

Dataset Information

Melioidosis in Patients with COVID-19 Exposed to Contaminated Tap Water, Thailand, 2021.

Publications

Melioidosis in Patients with COVID-19 Exposed to Contaminated Tap Water, Thailand, 2021.

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