Dataset Information

Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022.

ABSTRACT: In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community. Specific diagnostics and robust sequencing are needed to characterize multiple poxviruses and prevent potential poxvirus transmission.

SUBMITTER: Kalonji T

PROVIDER: S-EPMC10977837 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022.

Kalonji Thierry T Malembi Emile E Matela Jean Paul JP Likafi Toutou T Kinganda-Lusamaki Eddy E Vakaniaki Emmanuel Hasivirwe EH Hoff Nicole A NA Aziza Amuri A Muyembe Francisca F Kabamba Joelle J Cooreman Tine T Nguete Béatrice B Witte Danae D Ayouba Ahidjo A Fernandez-Nuñez Nicolas N Roge Stijn S Peeters Martine M Merritt Sydney S Ahuka-Mundeke Steve S Delaporte Eric E Pukuta Elisabeth E Mariën Joachim J Bangwen Eugene E Lakin Steven S Lewis Charles C Doty Jeffrey B JB Liesenborghs Laurens L Hensley Lisa E LE McCollum Andrea A Rimoin Anne W AW Muyembe-Tamfum Jean Jacques JJ Shongo Robert R Kaba Didine D Mbala-Kingebeni Placide P

Emerging infectious diseases 20240401 4

In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community. Specific diagnostics and robust sequencing are needed to characterize multiple poxviruses and prevent potential poxvirus transmission. ...[more]

PMID: 38526165

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Project description:INTRODUCTION:The establishment of the influenza sentinel surveillance system in Kinshasa, Bas Congo, Maniema, Katanga, and Kasai Provinces allowed generation of important data on the molecular epidemiology of human influenza viruses circulating in the Democratic Republic of Congo (DRC). However, some challenges still exist, including the need for extending the influenza surveillance to more provinces. This study describes the pattern of influenza virus circulating in DRC during 2015. METHODOLOGY:Nasopharyngeal swabs were collected from January to December 2015 from outpatients with influenza-like illness (ILI) and in all hospitalized patients with Severe Acute Respiratory Infection (SARI). Molecular analysis was done to determine influenza type and subtype at the National Reference Laboratory (NRL) in Kinshasa using real time reverse transcription-polymerase chain reaction (rRT-PCR). Analysis of antiviral resistance by enzyme inhibition assay and nucleotide sequencing was performed by the Collaborating center in the USA (CDC, Atlanta). RESULTS:Out of 2,376 nasopharyngeal swabs collected from patients, 218 (9.1%) were positive for influenza virus. Among the positive samples, 149 were characterized as influenza virus type A (Flu A), 67 as type B (Flu B) and 2 mixed infections (Flu A and B). Flu A subtypes detected were H3N2 and H1N1. The Yamagata strain of Flu B was detected among patients in the country. Individuals aged between 5 and 14 years accounted for the largest age group affected by influenza virus. All influenza viruses detected were found to be sensitive to antiviral drugs such as oseltamivar, zanamivir, peramivir and laninamivar. CONCLUSION:The present study documented the possible involvement of both circulation of Flu A and B viruses in human respiratory infection in certain DRC provinces during 2015. This study emphasises the need to extend the influenza surveillance to other provinces for a better understanding of the epidemiology of influenza in DRC. It is envisioned that such a system would lead to improved disease control and patient management.

Dataset Information

Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022.

Publications

Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022.

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