Meta-Research: Understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results.

ABSTRACT: Present-day publications on human genes primarily feature genes that already appeared in many publications prior to completion of the Human Genome Project in 2003. These patterns persist despite the subsequent adoption of high-throughput technologies, which routinely identify novel genes associated with biological processes and disease. Although several hypotheses for bias in the selection of genes as research targets have been proposed, their explanatory powers have not yet been compared. Our analysis suggests that understudied genes are systematically abandoned in favor of better-studied genes between the completion of -omics experiments and the reporting of results. Understudied genes remain abandoned by studies that cite these -omics experiments. Conversely, we find that publications o

SUBMITTER: Richardson R 

PROVIDER: S-EPMC10977968 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature