VoyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues.

ABSTRACT: We herein introduce voyAGEr, an online graphical interface to explore age-related gene expression alterations in 49 human tissues. voyAGEr offers a visualisation and statistical toolkit for the finding and functional exploration of sex- and tissue-specific transcriptomic changes with age. In its conception, we developed a novel bioinformatics pipeline leveraging RNA sequencing data, from the GTEx project, encompassing more than 900 individuals. voyAGEr reveals transcriptomic signatures of the known asynchronous ageing between tissues, allowing the observation of tissue-specific age periods of major transcriptional changes, associated with alterations in different biological pathways, cellular composition, and disease conditions. Notably, voyAGEr was created to assist researchers with no ex

SUBMITTER: Schneider AL 

PROVIDER: S-EPMC10977969 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature