Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour.

ABSTRACT: Grid firing fields have been proposed as a neural substrate for spatial localisation in general or for path integration in particular. To distinguish these possibilities, we investigate firing of grid and non-grid cells in the mouse medial entorhinal cortex during a location memory task. We find that grid firing can either be anchored to the task environment, or can encode distance travelled independently of the task reference frame. Anchoring varied between and within sessions, while spatial firing of non-grid cells was either coherent with the grid population, or was stably anchored to the task environment. We took advantage of the variability in task-anchoring to evaluate whether and when encoding of location by grid cells might contribute to behaviour. We find that when reward location

SUBMITTER: Clark H 

PROVIDER: S-EPMC10977970 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature