Serum from pregnant donors induces human beta cell proliferation.

ABSTRACT: Pancreatic beta cells are among the slowest replicating cells in the human body and have not been observed to increase in number except during the fetal and neonatal period, in cases of obesity, during puberty, as well as during pregnancy. Pregnancy is associated with increased beta cell mass to meet heightened insulin demands. This phenomenon raises the intriguing possibility that factors present in the serum of pregnant individuals may stimulate beta cell proliferation and offer insights into expansion of the beta cell mass for treatment and prevention of diabetes. The primary objective of this study was to test the hypothesis that serum from pregnant donors contains bioactive factors capable of inducing human beta cell proliferation. An immortalized human beta cell line with protracted

SUBMITTER: Sylvester-Armstrong KR 

PROVIDER: S-EPMC10978022 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature