Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies.

ABSTRACT:

Background

This study was designed to evaluate the effects of body mass index (BMI) and weight change on the risk of developing cancer overall and cancer at different sites.

Methods

We searched PubMed and other databases up to July 2023 using the keywords related to 'risk', 'cancer', 'weight', 'overweight', and 'obesity'. We identified eligible studies, and the inclusion criteria encompassed cohort studies in English that focused on cancer diagnosis and included BMI or weight change as an exposure factor. Multiple authors performed data extraction and quality assessment, and statistical analyses were carried out using RevMan and R software. We used random- or fixed-effects models to calculate the pooled relative risk (RR) or hazard ratio along with 95% confidence intervals (

SUBMITTER: Shi X 

PROVIDER: S-EPMC10978059 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature