Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice.

ABSTRACT: One-carbon metabolism is a complex network of metabolic reactions that are essential for cellular function including DNA synthesis. Vitamin B12 and folate are micronutrients that are utilized in this pathway and their deficiency can result in the perturbation of one-carbon metabolism and subsequent perturbations in DNA replication and repair. This effect has been well characterized in nuclear DNA but to date, mitochondrial DNA (mtDNA) has not been investigated extensively. Mitochondrial variants have been associated with several inherited and age-related disease states; therefore, the study of factors that impact heteroplasmy are important for advancing our understanding of the mitochondrial genome's impact on human health. Heteroplasmy studies require robust and efficient mitochondrial DN

SUBMITTER: Walsh DJ 

PROVIDER: S-EPMC10978065 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature