Hyperpolypharmacy is a predictor of mortality after left ventricular assist device (LVAD) implantation.

ABSTRACT:

Background

The prevalence of (hyper)polypharmacy in patients on left ventricular assist device (LVAD) support and its effect on clinical outcomeis unknown. Therefore, we aimed to determine the prevalence of (hyper)polypharmacy in LVAD patients and evaluate its association with mortality and complications.

Materials and methods

210 patients aged ≥40 years who received a primary LVAD implantation between 2011 and 2019 were included for analysis. Polypharmacy and hyperpolypharmacy were defined as the concomitant use of 5-9 and ≥10 medications at discharge after LVAD implantation, respectively. Cause specific cox regression was used to assess the association of ≥10 medications with mortality, cardiac arrhythmia, driveline infection and major bleeding.

Results

The median a

SUBMITTER: Dautzenberg L 

PROVIDER: S-EPMC10978416 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature