SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation.

ABSTRACT:

Background

In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The ability to tip the balance toward the hyperplastic growth, with recruitment of new fat cells through adipogenesis, seems to be critical for a healthy adipose tissue expansion, as opposed to a hypertrophic growth that is accompanied by the development of inflammation and metabolic dysfunction. However, the molecular mechanisms underlying the fine-tuned regulation of adipose tissue expansion are far from being understood.

Methods

We analyzed by mass spectrometry-based proteomics visceral white adipose tissue (vWAT) samples collected from C57BL6 mice fed with a HFD for 8 weeks. A subset of these mice, called low inflammation

SUBMITTER: Sajic T 

PROVIDER: S-EPMC10978492 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature