A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas.

ABSTRACT: The lack of properly perfused blood vessels within tumors can significantly hinder the distribution of drugs, leading to reduced treatment effectiveness and having a negative impact on the quality of life of patients with cancer. This problem is particularly pronounced in desmoplastic cancers, where interactions between cancer cells, stromal cells, and the fibrotic matrix lead to tumor stiffness and the compression of most blood vessels within the tumor. To address this issue, two mechanotherapy approaches-mechanotherapeutics and ultrasound sonopermeation-have been employed separately to treat vascular abnormalities in tumors and have reached clinical trials. Here, we performed in vivo studies in sarcomas, to explore the conditions under which these two mechanotherapy strategies could be o

SUBMITTER: Mpekris F 

PROVIDER: S-EPMC10978543 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature