Integrated plasma metabolomic and cytokine analysis reveals a distinct immunometabolic signature in atopic dermatitis.

ABSTRACT:

Importance

Disease models for atopic dermatitis (AD) have primarily focused on understanding underlying environmental, immunologic, and genetic etiologies. However, the role of metabolic mechanisms in AD remains understudied.

Objective

To investigate the circulating blood metabolomic and cytokine profile of AD as compared to healthy control patients.

Design

This study collected plasma from 20 atopic dermatitis with moderate-to-severe itch (score of ≥5 on the itch Numeric Rating Scale and IGA score ≥3) and 24 healthy control patients. Mass-spectrometry based metabolite data were compared between AD and healthy controls. Unsupervised and supervised machine learning algorithms and univariate analysis analyzed metabolic concentrations. Metabolite enrichment and pathway an

SUBMITTER: Ma EZ 

PROVIDER: S-EPMC10978712 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature