Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats.

ABSTRACT:

Background and aims

Ischemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after myocardial ischemia that recovers without permanent damage. The relationship between IPC and myocardial stunning remains incompletely understood. This study aimed primarily to examine the effects of IPC on the relationship between ischemia duration, stunning, and infarct size in an ischemia-reperfusion injury model. Secondarily, this study aimed to examine to which extent the phosphoproteomic changes induced by IPC relate to myocardial contractile function.

Methods and results

Rats were subjected to different durations of l

SUBMITTER: Elmahdy A 

PROVIDER: S-EPMC10978780 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature