Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance.

ABSTRACT: Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against blood-borne pathogens, are composed of heterogeneous subpopulations. Here, we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression levels. CD80^high MZ B cells exhibited greater Ab-producing, proliferative, and IL-10-secreting capacities than did CD80^low MZ B cells. Notably, CD80^high MZ B cells survived 2-Gy whole-body irradiation, whereas CD80^low MZ B cells were depleted by irradiation and then repleted with one month after irradiation. Depletion of CD80^low MZ B cells led to accelerated development of type II collagen (CII)-induced arthritis upon immunization with bovine CI

SUBMITTER: Lee S 

PROVIDER: S-EPMC10978899 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature