Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC10978915 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20240328 1
CRISPR/Cas9 technology has effectively targeted cancer-specific oncogenic hotspot mutations or insertion-deletions. However, their limited prevalence in tumors restricts their application. We propose a novel approach targeting passenger single nucleotide variants (SNVs) in haploinsufficient or essential genes to broaden therapeutic options. By disrupting haploinsufficient or essential genes through the cleavage of DNA in the SNV region using CRISPR/Cas9, we achieved the selective elimination of ...[more]