Periodontitis exacerbates pulmonary hypertension by promoting IFNγ⁺ T cell infiltration in mice.

ABSTRACT: Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease. In the current study, we showed that experimental periodontitis, which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis, exacerbated hypoxia-induced pulmonary hypertension in mice. Mechanistically, periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs, contributing to pulmonary infiltration of interferon gamma positive (IFNγ⁺) T cells and aggravating the progression of pulmonary hypertension. In addition, we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving t

SUBMITTER: Meng X 

PROVIDER: S-EPMC10978940 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature