Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis.

ABSTRACT: Effective management and control of parasitic infections on farms depends on their early detection. Traditional serological diagnostic methods for Fasciola hepatica infection in livestock are specific and sensitive, but currently the earliest detection of the parasite only occurs at approximately three weeks post-infection. At this timepoint, parasites have already entered the liver and caused the tissue damage and immunopathology that results in reduced body weight and loss in productivity. Here, we investigated whether the differential abundance of micro(mi)miRNAs in sera of F. hepatica-infected sheep has potential as a tool for the early diagnosis of infection. Using miRNA sequencing analysis, we discovered specific profiles of sheep miRNAs at both the pre-hepatic and hepatic infection

SUBMITTER: Chowdhury S 

PROVIDER: S-EPMC10978983 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature