Enhancing m⁶A modification of lncRNA through METTL3 and RBM15 to promote malignant progression in bladder cancer.

ABSTRACT:

Objective

Bladder cancer is one of the most prominent malignancies affecting the urinary tract, characterized by a poor prognosis. Our previous research has underscored the pivotal role of m⁶A methylation in the progression of bladder cancer. Nevertheless, the precise relationship between N6-methyladenosine (m⁶A) regulation of long non-coding RNA (lncRNA) and bladder cancer remains elusive.

Methods

This study harnessed sequencing data and clinical records from 408 bladder cancer patients in the TCGA database. Employing R software, we conducted bioinformatics analysis to establish an m⁶A-lncRNA co-expression network. Analyzing the differences between high and low-risk groups, particularly at the immunological level, and subsequently investigat

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10979072 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature