Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS^® 1541) on prostate hyperplasia and inflammation in rats and human cells.

ABSTRACT: Introduction: Phytotherapeutics, particularly extracts from Sabal serrulata (saw palmetto) fruit or Urtica dioica (stinging nettle) root, are popular for the treatment of male lower urinary symptoms in many countries, but their mechanism of action is poorly understood. We performed in vivo and in vitro studies to obtain deeper insight into the mechanism of action of WS^® 1541, a proprietary combination of a Sabal serrulata fruit and an Urtica dioica root extract (WS^® 1473 and WS^® 1031, respectively) and its components. Methods: We used the sulpiride model of benign prostatic hyperplasia in rats and tested three doses of WS^® 1541 in comparison to finasteride, evaluating weight of prostate and

SUBMITTER: Sens-Albert C 

PROVIDER: S-EPMC10979176 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature