Development and validation of a novel prognostic lncRNA signature based on the APOBEC3 family genes in gastric cancer.

ABSTRACT:

Introduction

Gastric Cancer (GC) refers to a prevalent malignant cancer accompanied by a weak prognosis. The APOBEC3 family genes and lncRNAs are linked with cancer progression. Nevertheless, there is still a scarcity of data concerning the prognostic value of APOBEC3-related lncRNAs in GC.

Methods

We extracted the data from GC samples, including transcriptome as well as clinical data, obtained from the TCGA database. Then, we screened for lncRNAs that were correlated with the APOBEC3 family genes and constructed an APOBEC3-related lncRNA prognostic signature (LPS) by utilizing univariate Cox and lasso regression analysis. Furthermore, we validated our constructed signature and evaluated it thoroughly, including analysis of its function, immunity, mutations, and clinical app

SUBMITTER: Qi J 

PROVIDER: S-EPMC10979227 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature