Real-world experience of teriflunomide in relapsing multiple sclerosis: paramagnetic rim lesions may play a role.

ABSTRACT:

Objectives

The aims of this study were to report the effectiveness and safety of teriflunomide in Chinese patients with relapsing-remitting multiple sclerosis (RRMS) and to explore the association of paramagnetic rim lesion (PRL) burden with patient outcome in the context of teriflunomide treatment and the impact of teriflunomide on PRL burden.

Methods

This is a prospective observational study. A total of 100 RRMS patients treated with teriflunomide ≥3 months were included in analyzing drug persistence and safety. Among them, 96 patients treated ≥6 months were included in assessing drug effectiveness in aspects of no evidence of disease activity (NEDA) 3. The number and total volume of PRL were calculated in 76 patients with baseline susceptibility-weighted imaging (SWI), an

SUBMITTER: Tan H 

PROVIDER: S-EPMC10979358 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature