Depressive Symptoms, Systemic Inflammation, and Survival Among Patients With Head and Neck Cancer.

ABSTRACT:

Importance

Patients with head and neck cancer experience high rates of depression. Depression and systemic inflammation have been found to be associated in numerous cancer types, often independently from disease status. Depression-related inflammation may elevate the risks for poor tumor response to treatment and early mortality, and comprises a mechanism by which depression is associated with survival in head and neck cancer.

Objective

To assess mediation pathways incorporating pretreatment depressive symptoms, pretreatment inflammation, and tumor response posttreatment on overall survival among patients with head and neck cancer.

Design, setting, and participants

This was a prospective observational cohort study of patients with head and neck cancer treated in a sin

SUBMITTER: Cash E 

PROVIDER: S-EPMC10979366 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature