Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products.

ABSTRACT: Achieving substrate-selectivity is a central element of nature's approach to synthesis. By relying on the ability of a catalyst to discriminate between components in a mixture, control can be exerted over which molecules will move forward in a synthesis. This approach can be powerful when realized but can be challenging to duplicate in the laboratory. In this work, substrate-selective catalysis is leveraged to discriminate between two intermediates that exist in equilibrium, subsequently directing the final cyclization to arrive at either the linear or angular tricyclic core common to subsets of azaphilone natural products. By using a flavin-dependent monooxygenase (FDMO) in sequence with an acyl transferase (AT), the conversion of several orcinaldehyde substrates directly to the correspon

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10979483 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature