Localized radiotherapy of solid tumors using radiopharmaceutical loaded implantable system: insights from a mathematical model.

ABSTRACT:

Introduction

Computational models yield valuable insights into biological interactions not fully elucidated by experimental approaches. This study investigates an innovative spatiotemporal model for simulating the controlled release and dispersion of radiopharmaceutical therapy (RPT) using ¹⁷⁷Lu-PSMA, a prostate-specific membrane antigen (PSMA) targeted radiopharmaceutical, within solid tumors via a dual-release implantable delivery system. Local delivery of anticancer agents presents a strategic approach to mitigate adverse effects while optimizing therapeutic outcomes.

Methods

This study evaluates various factors impacting RPT efficacy, including hypoxia region extension, binding affinity, and initial drug dosage, employing a novel 3-dimensional computational mo

SUBMITTER: Piranfar A 

PROVIDER: S-EPMC10979490 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature