Peripheral blood indicators and COVID-19: an observational and bidirectional Mendelian randomization study.

ABSTRACT: Blood is critical for health, supporting key functions like immunity and oxygen transport. While studies have found links between common blood clinical indicators and COVID-19, they cannot provide causal inference due to residual confounding and reverse causality. To identify indicators affecting COVID-19, we analyzed clinical data (n = 2,293, aged 18-65 years) from Guangzhou Medical University's first affiliated hospital (2022-present), identifying 34 significant indicators differentiating COVID-19 patients from healthy controls. Utilizing bidirectional Mendelian randomization analyses, integrating data from over 2.46 million participants from various large-scale studies, we established causal links for six blood indicators with COVID-19 risk, five of which is consistent with our observat

SUBMITTER: Chang Z 

PROVIDER: S-EPMC10979573 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature