Minocycline-loaded nHAP/PLGA microspheres for prevention of injury-related corneal angiogenesis.

ABSTRACT:

Background

Corneal neovascularization (CoNV) threatens vision by disrupting corneal avascularity, however, current treatments, including pharmacotherapy and surgery, are hindered by limitations in efficacy and adverse effects. Minocycline, known for its anti-inflammatory properties, could suppress CoNV but faces challenges in effective delivery due to the cornea's unique structure. Therefore, in this study a novel drug delivery system using minocycline-loaded nano-hydroxyapatite/poly (lactic-co-glycolic acid) (nHAP/PLGA) nanoparticles was developed to improve treatment outcomes for CoNV.

Results

Ultra-small nHAP was synthesized using high gravity technology, then encapsulated in PLGA by a double emulsion method to form nHAP/PLGA microspheres, attenuating the acidic by-produc

SUBMITTER: Li Z 

PROVIDER: S-EPMC10979583 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature