Management of Older Adults with Sickle Cell Disease: Considerations for Current and Emerging Therapies.

ABSTRACT: People with sickle cell disease (SCD) are living longer than ever before, with the median survival increasing from age 14 years in 1973, beyond age 40 years in the 1990s, and as high as 61 years in recent cohorts from academic centers. Improvements in survival have been attributed to initiatives, such as newborn screening, penicillin prophylaxis, vaccination against encapsulated organisms, better detection and treatment of splenic sequestration, and improved transfusion support. There are an estimated 100,000 people living with SCD in the United States and millions of people with SCD globally. Given that the number of older adults with SCD will likely continue to increase as survival improves, better evidence on how to manage this population is needed. When managing older adults with SCD (

SUBMITTER: Oyedeji CI 

PROVIDER: S-EPMC10979738 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature