Reactive microglia fail to respond to environmental damage signals in a viral-induced mouse model of temporal lobe epilepsy.

ABSTRACT: Microglia are highly adaptable innate immune cells that rapidly respond to damage signals in the brain through adoption of a reactive phenotype and production of defensive inflammatory cytokines. Microglia express a distinct transcriptome, encoding receptors that allow them to dynamically respond to pathogens, damage signals, and cellular debris. Expression of one such receptor, the microglia-specific purinergic receptor P2ry12, is known to be downregulated in reactive microglia. Here, we explore the microglial response to purinergic damage signals in reactive microglia in the TMEV mouse model of viral brain infection and temporal lobe epilepsy. Using two-photon calcium imaging in acute hippocampal brain slices, we found that the ability of microglia to detect damage signals, engage

SUBMITTER: Wallis GJ 

PROVIDER: S-EPMC10979929 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature