Multiscale computational model predicts how environmental changes and drug treatments affect microvascular remodeling in fibrotic disease.

ABSTRACT: Investigating the molecular, cellular, and tissue-level changes caused by disease, and the effects of pharmacological treatments across these biological scales, necessitates the use of multiscale computational modeling in combination with experimentation. Many diseases dynamically alter the tissue microenvironment in ways that trigger microvascular network remodeling, which leads to the expansion or regression of microvessel networks. When microvessels undergo remodeling in idiopathic pulmonary fibrosis (IPF), functional gas exchange is impaired due to loss of alveolar structures and lung function declines. Here, we integrated a multiscale computational model with independent experiments to investigate how combinations of biomechanical and biochemical cues in IPF alter cell fate decisions

SUBMITTER: Leonard-Duke J 

PROVIDER: S-EPMC10979947 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature