Adoptive transfer of CD49a⁺ Tissue resident memory cells reverses pulmonary fibrosis in mice.

ABSTRACT: Pulmonary fibrosis is a devastating disease with no effective treatments to cure, stop or reverse the unremitting, fatal fibrosis. A critical barrier to treating this disease is the lack of understanding of the pathways leading to fibrosis as well as those regulating the resolution of fibrosis. Fibrosis is the pathologic side of normal tissue repair that results when the normal wound healing programs go awry. Successful resolution of tissue injury requires several highly coordinated pathways, and this research focuses on the interplay between these overlapping pathways: immune effectors, inflammatory mediators and fibroproliferation in the resolution of fibrosis. Previously we have successfully prevented, mitigated, and even reversed established fibrosis using vaccinia vaccination immunoth

SUBMITTER: Collins SL 

PROVIDER: S-EPMC10980005 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature