Tstrait: a quantitative trait simulator for ancestral recombination graphs.

ABSTRACT:

Summary

Ancestral recombination graphs (ARGs) encode the ensemble of correlated genealogical trees arising from recombination in a compact and efficient structure, and are of fundamental importance in population and statistical genetics. Recent breakthroughs have made it possible to simulate and infer ARGs at biobank scale, and there is now intense interest in using ARG-based methods across a broad range of applications, particularly in genome-wide association studies (GWAS). Sophisticated methods exist to simulate ARGs using population genetics models, but there is currently no software to simulate quantitative traits directly from these ARGs. To apply existing quantitative trait simulators users must export genotype data, losing important information about ancestral processes and

SUBMITTER: Tagami D 

PROVIDER: S-EPMC10980058 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature