Metabolomic profiles in Jamaican children with and without autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a wide range of behavioral and cognitive impairments. While genetic and environmental factors are known to contribute to its etiology, the underlying metabolic perturbations associated with ASD which can potentially connect genetic and environmental factors, remain poorly understood. Therefore, we conducted a metabolomic case-control study and performed a comprehensive analysis to identify significant alterations in metabolite profiles between children with ASD and typically developing (TD) controls.

Objective

To elucidate potential metabolomic signatures associated with ASD in children and identify specific metabolites that may serve as biomarkers for the disorder.

Methods

We con

SUBMITTER: Yazdani A 

PROVIDER: S-EPMC10980079 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature