Ontology highlight
ABSTRACT:
SUBMITTER: Burrows K
PROVIDER: S-EPMC10980110 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Burrows Kimberley K Heiskala Anni A Bradfield Jonathan P JP Balkhiyarova Zhanna Z Ning Lijiao L Boissel Mathilde M Chan Yee-Ming YM Froguel Philippe P Bonnefond Amelie A Hakonarson Hakon H Alves Alessander Couto AC Lawlor Deborah A DA Kaakinen Marika M Järvelin Marjo-Riitta MR Grant Struan F A SFA Tilling Kate K Prokopenko Inga I Sebert Sylvain S Canouil Mickaël M Warrington Nicole M NM
medRxiv : the preprint server for health sciences 20240316
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in genome-wide association studies (GWASs). Using childhood body mass index (BMI) as an example, we included 71,336 participants from six cohorts and estimated the slope and area under th ...[more]