Dietary Factors Affect Brain Iron Accumulation and Parkinson's Disease Risk.

ABSTRACT:

Importance

Iron dysregulation in the brain has been associated with neurodegenerative diseases like Parkinson's Disease (PD). Iron is exclusively absorbed from food; therefore, dietary patterns may impact risk.

Objective

To understand how modifiable dietary factors are associated with brain iron accumulation and PD risk.

Design

This retrospective cohort study included participants from the UK Biobank, a population-based sample. Genotypes, MRI scans, demographics, diagnoses, and diet and lifestyle measures were collected from January 2006 to May 2021. Data analysis was conducted from September 2023 to June 2024.

Setting

population-based.

Participants

Disorders analyzed included Parkinson's and Parkinsonian Disorders (PD) (International Statistical Classif

SUBMITTER: Ahern J 

PROVIDER: S-EPMC10980125 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature