Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.

ABSTRACT: The nematode Caenorhabditis elegans is a widely used model organism for neuroscience. Although its nervous system has been fully reconstructed, the physiological bases of single-neuron functioning are still poorly explored. Recently, many efforts have been dedicated to measuring signals from C. elegans neurons, revealing a rich repertoire of dynamics, including bistable responses, graded responses, and action potentials. Still, biophysical models able to reproduce such a broad range of electrical responses lack. Realistic electrophysiological descriptions started to be developed only recently, merging gene expression data with electrophysiological recordings, but with a large variety of cells yet to be modeled. In this work, we contribute to filling this gap by providing biophysically accu

SUBMITTER: Nicoletti M 

PROVIDER: S-EPMC10980225 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature