Identification of a predictive gene signature related to pyroptosis for the prognosis of cutaneous melanoma.

ABSTRACT: Pyroptosis is a form of inflammatory programmed cell death. However, because of no specific molecular biomarker, pyroptosis has not been considered as a novel therapeutic method to treat cutaneous melanoma (CM). Here, we identified pyroptosis genes that associate with the prognosis of CM patients and constructed an effective model for the prognostic prediction of CM patients. To identify genes related to pyroptosis that are differentially expressed in CM, we obtained gene expression data of CM patients and normal skin tissues from the Cancer Genome Atlas and the Genotype-Tissue Expression databases, and used another cohort obtained from Gene Expression Omnibus database for validation. Three genes (BST2, GBP5, and AIM2) that were associated with prognosis were found and incorporated into ou

SUBMITTER: Shi Z 

PROVIDER: S-EPMC10980462 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature