Enhanced antibacterial activity of porous chitosan-based hydrogels crosslinked with gelatin and metal ions.

ABSTRACT: Addressing the increasing drug resistance in pathogenic microbes, a significant threat to public health, calls for the development of innovative antibacterial agents with versatile capabilities. To enhance the antimicrobial activity of non-toxic biomaterials in this regard, this study focuses on novel, cost-effective chitosan (CS)-based hydrogels, crosslinked using gelatin (GEL), formaldehyde, and metallic salts (Ag⁺, Cu²⁺, and Zn²⁺). These hydrogels are formed by mixing CS and GEL with formaldehyde, creating iminium ion crosslinks with metallic salts without hazardous crosslinkers. Characterization techniques like FTIR, XRD, FESEM, EDX, and rheological tests were employed. FTIR analysis showed metal ions binding to amino and hydroxyl groups on CS, enhancin

SUBMITTER: Farasati Far B 

PROVIDER: S-EPMC10980704 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature