Predictive three-biomarker panel in peripheral blood mononuclear cells for detecting hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) ranks among the most prevalent cancers and accounts for a significant proportion of cancer-associated deaths worldwide. This disease, marked by multifaceted etiology, often poses diagnostic challenges. Finding a reliable and non-invasive diagnostic method seems to be necessary. In this study, we analyzed the gene expression profiles of 20 HCC patients, 12 individuals with chronic hepatitis, and 15 healthy controls. Enrichment analysis revealed that platelet aggregation, secretory granule lumen, and G-protein-coupled purinergic nucleotide receptor activity were common biological processes, cellular components, and molecular function in HCC and chronic hepatitis B (CHB) compared to healthy controls, respectively. Furthermore, pathway analysis demonstrated that

SUBMITTER: Fayazzadeh S 

PROVIDER: S-EPMC10980807 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature