Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain.

ABSTRACT:

Background

Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. Here we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability, and an in vivo rat model of AD to test whether such plasma impacts cognitive function, amyloid pathology, and neurogenesis.

Methods

Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-β and treated with plasma collected from human male donors 3 h after a single bout of high-intensity exercise. For in vivo studies, blood was collected from exercise-trained young male Wistar rats (high-intensity intervals 5 da

SUBMITTER: Norevik CS 

PROVIDER: S-EPMC10980897 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature