Outcomes with guideline-directed medical therapy and cardiac implantable electronic device therapies for patients with heart failure with reduced ejection fraction.

ABSTRACT:

Background

Limited real-world evidence exists for outcomes with contemporary guideline-directed medical therapy (GDMT) or GDMT with implantable cardioverter-defibrillator (ICD)/cardiac resynchronization therapy defibrillator (CRT-D) therapy for patients with heart failure with reduced ejection fraction (HFrEF) and left ventricular ejection fraction (LVEF) ≤35%.

Objective

The present study aimed to assess survival associated with GDMT or GDMT with ICD/CRT-D therapy.

Methods

This retrospective observational study included real-world de-identified data from January 1, 2016, to December 19, 2023, from 24 U.S. institutions per participating institutional agreements (egnite Database; egnite, Inc.). Patients with a diagnosis of HFrEF and an echocardiographic study documentin

SUBMITTER: Mignone JL 

PROVIDER: S-EPMC10980920 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature