Identification and verification of AK4 as a protective immune-related biomarker in adipose-derived stem cells and breast cancer.

ABSTRACT:

Background

Breast cancer (BC) remains the most common cancer among women, and novel post-surgical reconstruction techniques, including autologous fat transplantation, have emerged. While Adipose-derived stem cells (ADSCs) are known to impact the viability of fat grafts, their influence on breast cancer progression remains unclear. This study aims to elucidate the genetic interplay between ADSCs and breast cancer, focusing on potential therapeutic targets.

Methods

Using the GEO and TCGA databases, we pinpointed differentially expressed (DE) mRNAs, miRNAs, lncRNAs, and pseudogenes of ADSCs and BC. We performed functional enrichment analysis and constructed protein-protein interaction (PPI), RNA binding protein (RBP)-pseudogene-mRNA, and lncRNA-miRNA-transcription factor (TF)-g

SUBMITTER: Lu W 

PROVIDER: S-EPMC10980947 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature