Interassay Variability and Clinical Implications of Five Different Prostate-specific Antigen Assays.

ABSTRACT:

Background and objective

Prostate-specific antigen (PSA) remains a critical marker for prostate cancer (PCa) detection and monitoring. Recognising historical variability in PSA assays and the evolution of assay technology and calibration, this study aims to reassess interassay variability using the latest generation of five assays in a contemporary cohort of men undergoing prostate biopsy.

Methods

Five different commercially available PSA assays were tested in a blood sample of 76 men before undergoing a prostate biopsy. Total PSA (tPSA) and free-to-total PSA ratio (%fPSA) were compared across assays, using Roche (Basel, Switzerland) as the benchmark, and correlated with biopsy outcome to analyse the impact on PCa diagnosis. The statistical analysis included Passing-Bablok r

SUBMITTER: Kaufmann B 

PROVIDER: S-EPMC10981008 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature