The potential impact of polymorphisms in METTL3 gene on knee osteoarthritis susceptibility.

ABSTRACT:

Objective

This study was aimed to explore the correlation between METTL3 polymorphisms and susceptibility to knee osteoarthritis (KOA).

Methods

The relationship of five single nucleotide polymorphisms (SNPs) in the METTL3 gene with the susceptibility of KOA was analyzed through multinomial logistic regression analysis in this a case-control study. Genotyping was performed on 228 KOA patients and 252 unaffected individuals from South China based on the TaqMan method. The MDR software (version 3.0.2) was utilized for the analysis of SNP interactions.

Results

Out of the five SNPs examined, the T > G change in the METTL3 gene at the rs1061026 locus increased the risk of KOA, while rs1139130 A > G and rs1263802 C > T variants were found to be linked wi

SUBMITTER: Mi H 

PROVIDER: S-EPMC10981020 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature