Lung adenocarcinoma patients with ROS1-rearranged tumors by sex and smoking intensity.

ABSTRACT:

Background

ROS1 rearrangements (ROS1+) define a distinct molecular subset of lung adenocarcinomas. ROS1 + tumors are known to occur more in never-smokers, but the frequency and outcome of ROS1 positivity by sex and smoking intensity are not clearly documented.

Patients and methods

This patient cohort study included all never- (<100 cigarettes lifetime) and light- (100 cigarettes-20 pack-years) smokers, and a sample of heavy-smokers. ROS1 + rates by sex and smoking intensity were compared within and beyond our study. Survival outcomes were analyzed using Kaplan-Meier curves and Cox proportional hazards models.

Results

Of the 571 total patients, ROS1 + was detected in 24 (4.2%): 6.4% in men and 3.0% in women; 5.1% in never-, 5.7

SUBMITTER: Peng Y 

PROVIDER: S-EPMC10981064 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature